SEPT2 Antibody

Product Specifications

Background

Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.

NCBI Gene ID

4735

Swiss Prot

Q15019

Accession Number

Q15019

Host

Rabbit

Reactivity

Human

Immunogen

This SEPT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 280-309 amino acids from the C-terminal region of human SEPT2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

41 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SEPT2

NCBI Official Name

Septin-2

NCBI Organism

Homo sapiens

Background Reference 01

Martins-de-Souza, D., et al.Psychiatr Res (2010) In press :

Background Reference 02

Guey, L.T., et al. Eur. Urol. 57 (2) :283-292 (2010)

Background Reference 03

Hosgood, H.D. III, et al. Respir Med 103 (12) :1866-1870 (2009)

Background Reference 04

Shen, M., et al. Environ. Mol. Mutagen. 50 (4) :285-290 (2009)

Other Product Names

Septin-2, Neural precursor cell expressed developmentally down-regulated protein 5, NEDD-5, SEPT2, DIFF6, KIAA0158, NEDD5

Tested Applications

Protein ID

2500769

Physical Properties

Liquid

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