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TRPC4 Antibody

Product Specifications

Background

Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.

NCBI Gene ID

7223

Swiss Prot

Q9UBN4

Accession Number

Q9UBN4

Host

Rabbit

Reactivity

Human

Immunogen

This TRPC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 812-840 amino acids from the C-terminal region of human TRPC4.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=58-703

Calculated Molecular Weight

112 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

TRPC4

NCBI Official Name

Short transient receptor potential channel 4

NCBI Organism

Homo sapiens

Background Reference 01

Mace, K.E., et al. J. Cell. Physiol. 225 (2) :444-453 (2010)

Background Reference 02

Von Spiczak, S., et al. Neuromolecular Med. 12 (3) :292-299 (2010)

Background Reference 03

Pinheiro, A.P., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :

Background Reference 04

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

Other Product Names

Short transient receptor potential channel 4, TrpC4, Trp-related protein 4, hTrp-4, hTrp4, TRPC4

Tested Applications

WB

Protein ID

13633994

Physical Properties

Liquid

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