DRD2 Antibody

Product Specifications

Background

This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.

NCBI Gene ID

1813

Swiss Prot

P14416

Accession Number

P14416

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This DRD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-336 amino acids from the C-terminal region of human DRD2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction, Growth Factors

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

51 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:2000

Symbol

DRD2

NCBI Official Name

D (2) dopamine receptor

NCBI Organism

Homo sapiens

Background Reference 01

Verma, V., et al. J. Biol. Chem. 285 (45) :35092-35103 (2010)

Background Reference 02

Borroto-Escuela, D.O., et al. Biochem. Biophys. Res. Commun. 401 (4) :605-610 (2010)

Background Reference 03

Stelzel, C., et al. J. Neurosci. 30 (42) :14205-14212 (2010)

Background Reference 04

Huang, H.Y., et al. J. Formos. Med. Assoc. 109 (10) :736-739 (2010)

Other Product Names

D (2) dopamine receptor, Dopamine D2 receptor, DRD2

Tested Applications

Protein ID

118206

Physical Properties

Liquid

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