ARHGEF6 Antibody

Product Specifications

Background

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq].

NCBI Gene ID

9459

Swiss Prot

Q15052

Accession Number

Q15052

Host

Rabbit

Reactivity

Human

Immunogen

This ARHGEF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 614-641 amino acids from the C-terminal region of human ARHGEF6.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

87 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

ARHGEF6

NCBI Official Name

Rho guanine nucleotide exchange factor 6

NCBI Organism

Homo sapiens

Background Reference 01

Maiti, A.K. Pharmacogenomics J. 10 (2) :94-104 (2010)

Background Reference 02

Eriguchi, M., et al. J. Neurol. Sci. 290 (1-2), 80-85 (2010) :

Background Reference 03

Takefuji, M., et al. J. Hum. Genet. 55 (1) :42-49 (2010)

Background Reference 04

Lim, J.W., et al. Scand. J. Gastroenterol. 44 (10) :1166-1172 (2009)

Other Product Names

Rho guanine nucleotide exchange factor 6, Alpha-Pix, COOL-2, PAK-interacting exchange factor alpha, Rac/Cdc42 guanine nucleotide exchange factor 6, ARHGEF6, COOL2, KIAA0006, PIXA