CLCN2 Antibody

Product Specifications

Background

The transmembrane protein encoded by this gene is a voltage-gated chloride channel that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

1181

Swiss Prot

P51788

Accession Number

P51788

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This CLCN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 209-237 amino acids from the N-terminal region of human CLCN2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rabbit, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

99 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CLCN2

NCBI Official Name

Chloride channel protein 2

NCBI Organism

Homo sapiens

Background Reference 01

Scheper, G.C., et al. Genet Test Mol Biomarkers 14 (2) :255-257 (2010)

Background Reference 02

Cornejo, I., et al. J. Cell. Physiol. 221 (3) :650-657 (2009)

Background Reference 03

Thompson, C.H., et al. J. Biol. Chem. 284 (38) :26051-26062 (2009)

Background Reference 04

Kleefuss-Lie, A., et al. Nat. Genet. 41 (9) :954-955 (2009)

Other Product Names

Chloride channel protein 2, ClC-2, CLCN2

Tested Applications

Protein ID

288558807

Physical Properties

Liquid

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