PTPN22 Antibody

Product Specifications

Background

This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.

NCBI Gene ID

26191

Swiss Prot

Q9Y2R2

Accession Number

Q9Y2R2

Host

Rabbit

Reactivity

Human

Immunogen

This PTPN22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 663-691 amino acids from the C-terminal region of human PTPN22.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

92 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PTPN22

NCBI Official Name

Tyrosine-protein phosphatase non-receptor type 22

NCBI Organism

Homo sapiens

Background Reference 01

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 02

Andersen, M.K., et al. Diabetes Care 33 (9) :2062-2064 (2010)

Background Reference 03

Bianco, B., et al. Scand. J. Immunol. 72 (3) :256-259 (2010)

Background Reference 04

Pradhan, V., et al.Postgrad Med 56 (3) :239-242 (2010)

Other Product Names

Tyrosine-protein phosphatase non-receptor type 22, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, Lymphoid phosphatase, LyP, PEST-domain phosphatase, PEP, PTPN22, PTPN8