AKR1D1 Antibody

Product Specifications

Background

The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta (4) -3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. Three transcript variants encoding different isoforms have been found for this gene. Other variants may be present, but their full-length natures have not been determined yet.

NCBI Gene ID

6718

Swiss Prot

P51857

Accession Number

P51857

Host

Rabbit

Reactivity

Human

Immunogen

This AKR1D1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-139 amino acids from the Central region of human AKR1D1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

37 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

AKR1D1

NCBI Official Name

3-oxo-5-beta-steroid 4-dehydrogenase

NCBI Organism

Homo sapiens

Background Reference 01

Steen, N.E., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry (2010) In press :

Background Reference 02

Drury, J.E., et al. J. Biol. Chem. 285 (32) :24529-24537 (2010)

Background Reference 03

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

Background Reference 04

Ueki, I., et al. J. Gastroenterol. Hepatol. 24 (5) :776-785 (2009)

Other Product Names

3-oxo-5-beta-steroid 4-dehydrogenase, Aldo-keto reductase family 1 member D1, Delta (4) -3-ketosteroid 5-beta-reductase, Delta (4) -3-oxosteroid 5-beta-reductase, AKR1D1, SRD5B1