ACSL3 Antibody

Product Specifications

Background

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene.

NCBI Gene ID

2181

Swiss Prot

O95573

Accession Number

O95573

Host

Rabbit

Reactivity

Human

Immunogen

This ACSL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 528-556 amino acids from the C-terminal region of human ACSL3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

80 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

ACSL3

NCBI Official Name

Long-chain-fatty-acid--CoA ligase 3

NCBI Organism

Homo sapiens

Background Reference 01

Weedon-Fekjaer, M.S., et al. J. Lipid Res. 51 (7) :1886-1896 (2010)

Background Reference 02

Cao, A., et al. J. Biol. Chem. 285 (22) :16664-16674 (2010)

Background Reference 03

Perera, F., et al. PLoS ONE (2), E4488 (2009) :

Background Reference 04

Yao, H., et al. J. Biol. Chem. 283 (2) :849-854 (2008)

Other Product Names

Long-chain-fatty-acid--CoA ligase 3, Long-chain acyl-CoA synthetase 3, LACS 3, ACSL3, ACS3, FACL3, LACS3

Tested Applications

Physical Properties

Liquid

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