RNF34 Antibody
Product Specifications
Background
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
NCBI Gene ID
80196
Swiss Prot
Q969K3
Accession Number
Q969K3
Host
Rabbit
Reactivity
Human
Immunogen
This RNF34 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-311 amino acids from the C-terminal region of human RNF34.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
42 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
RNF34
NCBI Official Name
E3 ubiquitin-protein ligase RNF34
NCBI Organism
Homo sapiens
Background Reference 01
Erlbruch, A., et al. Proteomics 10 (16) :2890-2900 (2010)
Background Reference 02
Yang, W., et al. Cell Cycle 7 (5) :670-682 (2008)
Background Reference 03
Yang, W., et al. J. Biol. Chem. 282 (5) :3273-3281 (2007)
Background Reference 04
Konishi, T., et al. Mol. Cancer Ther. 4 (5) :743-750 (2005)
Other Product Names
HGNC:17297
Tested Applications
WB
Protein ID
74760679
Physical Properties
Liquid
Curated Selection
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