SNUPN Antibody
Product Specifications
Background
The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.
NCBI Gene ID
10073
Swiss Prot
O95149
Accession Number
O95149
Host
Rabbit
Reactivity
Human
Immunogen
This SNUPN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-228 amino acids from the Central region of human SNUPN.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
41 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SNUPN
NCBI Official Name
Snurportin-1
NCBI Organism
Homo sapiens
Background Reference 01
Goette, M., et al. Biophys. J. 97 (2) :581-589 (2009)
Background Reference 02
Monecke, T., et al. Science 324 (5930) :1087-1091 (2009)
Background Reference 03
Ospina, J.K., et al. Mol. Biol. Cell 16 (10) :4660-4671 (2005)
Background Reference 04
Stelzl, U., et al. Cell 122 (6) :957-968 (2005)
Other Product Names
Snurportin-1, RNA U transporter 1, SNUPN, RNUT1, SPN1
Tested Applications
WB
Physical Properties
Liquid
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