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EPB49 Antibody

Product Specifications

Background

Dematin, or EPB49, is an actin-bundling protein originally identified in the erythroid membrane skeleton. Its actin-bundling activity is abolished upon phosphorylation by cAMP-dependent protein kinase and is restored after dephosphorylation (Rana et al., 1993 [PubMed 8341682]) .

NCBI Gene ID

2039

Swiss Prot

Q08495

Accession Number

Q08495

Host

Rabbit

Reactivity

Human

Immunogen

This EPB49 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 249-277 amino acids from the Central region of human EPB49.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=58-591

Calculated Molecular Weight

46 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

DMTN

NCBI Official Name

Dematin

NCBI Organism

Homo sapiens

Background Reference 01

Vugmeyster, L., et al. J. Biomol. NMR 47 (2) :155-162 (2010)

Background Reference 02

Chen, L., et al. Protein Sci. 18 (3) :629-636 (2009)

Background Reference 03

Vugmeyster, L., et al. J. Biomol. NMR 43 (1) :39-50 (2009)

Background Reference 04

Vermeulen, W., et al. J. Mol. Biol. 359 (5) :1277-1292 (2006)

Other Product Names

Dematin, Dematin actin-binding protein, Erythrocyte membrane protein band 49, DMTN, DMT, EPB49

Tested Applications

WB

Protein ID

22654240

Physical Properties

Liquid

Curated Selection

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