KATNB1 Antibody

Product Specifications

Background

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1) . The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases.

NCBI Gene ID

10300

Swiss Prot

Q9BVA0

Accession Number

Q9BVA0

Host

Rabbit

Reactivity

Human

Immunogen

This KATNB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 331-359 amino acids from the Central region of human KATNB1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

72 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

KATNB1

NCBI Official Name

Katanin p80 WD40 repeat-containing subunit B1 {ECO:0000255|HAMAP-Rule:MF_03022}

NCBI Organism

Homo sapiens

Background Reference 01

Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :

Background Reference 02

Cummings, C.M., et al. J. Biol. Chem. 284 (17) :11663-11675 (2009)

Background Reference 03

Sudo, H., et al. Hum. Mol. Genet. 17 (16) :2524-2540 (2008)

Background Reference 04

Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)

Other Product Names

Katanin p80 WD40 repeat-containing subunit B1 {ECO:0000255|HAMAP-Rule:MF_03022}, Katanin p80 subunit B1 {ECO:0000255|HAMAP-Rule:MF_03022}, p80 katanin {ECO:0000255|HAMAP-Rule:MF_03022}, KATNB1 {ECO:0000255|HAMAP-Rule:MF_03022}