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DIAPH3 Antibody

Product Specifications

Background

DIAPH3 binds to GTP-bound form of Rho and to profilin. Acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. It is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity) .

NCBI Gene ID

81624

Swiss Prot

Q9NSV4

Accession Number

Q9NSV4

Host

Rabbit

Reactivity

Human

Immunogen

This DIAPH3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1061-1090 amino acids from the C-terminal region of human DIAPH3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=58-585

Calculated Molecular Weight

137 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

DIAPH3

NCBI Official Name

Protein diaphanous homolog 3

NCBI Organism

Homo sapiens

Background Reference 01

DeWard, A.D., et al. J. Biol. Chem. 284 (30) :20061-20069 (2009)

Background Reference 02

Block, J., et al.Microsc 231 (3) :506-517 (2008)

Background Reference 03

Beli, P., et al. Nat. Cell Biol. 10 (7) :849-857 (2008)

Background Reference 04

Yang, C., et al. PLoS Biol. (11), E317 (2007) :

Other Product Names

Protein diaphanous homolog 3, Diaphanous-related formin-3, DRF3, MDia2, DIAPH3, DIAP3

Tested Applications

WB

Protein ID

158520000

Physical Properties

Liquid

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