DIAPH3 Antibody
Product Specifications
Background
DIAPH3 binds to GTP-bound form of Rho and to profilin. Acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. It is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity) .
NCBI Gene ID
81624
Swiss Prot
Q9NSV4
Accession Number
Q9NSV4
Host
Rabbit
Reactivity
Human
Immunogen
This DIAPH3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1061-1090 amino acids from the C-terminal region of human DIAPH3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
137 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
DIAPH3
NCBI Official Name
Protein diaphanous homolog 3
NCBI Organism
Homo sapiens
Background Reference 01
DeWard, A.D., et al. J. Biol. Chem. 284 (30) :20061-20069 (2009)
Background Reference 02
Block, J., et al.Microsc 231 (3) :506-517 (2008)
Background Reference 03
Beli, P., et al. Nat. Cell Biol. 10 (7) :849-857 (2008)
Background Reference 04
Yang, C., et al. PLoS Biol. (11), E317 (2007) :
Other Product Names
Protein diaphanous homolog 3, Diaphanous-related formin-3, DRF3, MDia2, DIAPH3, DIAP3
Tested Applications
WB
Protein ID
158520000
Physical Properties
Liquid
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