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ATF3 Antibody

Product Specifications

Background

Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes.

NCBI Gene ID

467

Swiss Prot

P18847

Accession Number

P18847

Host

Rabbit

Reactivity

Human

Immunogen

This ATF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-168 amino acids from the C-terminal region of human ATF3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat, Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=58-581

Calculated Molecular Weight

21 kDa

Fragment

Rabbit Ig

Symbol

ATF3

NCBI Official Name

Cyclic AMP-dependent transcription factor ATF-3

NCBI Organism

Homo sapiens

Background Reference 01

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 02

Lee, S.H., et al. Oncogene 29 (37) :5182-5192 (2010)

Background Reference 03

Park, H.J., et al. Biochem. Biophys. Res. Commun. 400 (1) :72-77 (2010)

Background Reference 04

Wu, X., et al. Nature 465 (7296) :368-372 (2010)

Other Product Names

Cyclic AMP-dependent transcription factor ATF-3, cAMP-dependent transcription factor ATF-3, Activating transcription factor 3, ATF3

Tested Applications

WB, Flow

Protein ID

1168543

Physical Properties

Liquid

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