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TTL Antibody

Product Specifications

Background

TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529) . Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]) .

NCBI Gene ID

150465

Swiss Prot

Q8NG68

Accession Number

Q8NG68

Host

Rabbit

Reactivity

Human

Immunogen

This TTL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 232-263 amino acids from the C-terminal region of human TTL.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Pig, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=58-579

Calculated Molecular Weight

43 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

TTL

NCBI Official Name

Tubulin--tyrosine ligase

NCBI Organism

Homo sapiens

Background Reference 01

Dick, D.M., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 153B (6), 1179-1188 (2010) :

Background Reference 02

Erck, C., et al. Cytogenet. Genome Res. 101 (1) :47-53 (2003)

Background Reference 03

Mialhe, A., et al. Cancer Res. 61 (13) :5024-5027 (2001)

Background Reference 04

Ersfeld, K., et al. J. Cell Biol. 120 (3) :725-732 (1993)

Other Product Names

Tubulin--tyrosine ligase, TTL, TTL

Tested Applications

WB

Protein ID

47117358

Physical Properties

Liquid

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