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SH3PXD2A Antibody

Product Specifications

Background

SH3PXD2A is required for podosome formation, degradation of the extracellular matrix, and for the invasiveness of some cancer cells. Binds phosphatidylinositol 3-phosphate (PtdIns (3) P) and phosphatidylinositol 3,4-biphosphate (PtdIns (3,4) P2) . In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.

NCBI Gene ID

9644

Swiss Prot

Q5TCZ1

Accession Number

Q5TCZ1

Host

Rabbit

Reactivity

Human

Immunogen

This SH3PXD2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 222-250 amino acids from the N-terminal region of human SH3PXD2A.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=58-571

Calculated Molecular Weight

125 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SH3PXD2A

NCBI Official Name

SH3 and PX domain-containing protein 2A

NCBI Organism

Homo sapiens

Background Reference 01

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

Background Reference 02

Laumet, G., et al. Neurosci. Lett. 468 (1) :1-2 (2010)

Background Reference 03

Crimaldi, L., et al. Exp. Cell Res. 315 (15) :2581-2592 (2009)

Background Reference 04

Voss, M., et al. BMC Immunol. 10, 53 (2009) :

Other Product Names

SH3 and PX domain-containing protein 2A, Adapter protein TKS5, Five SH3 domain-containing protein, SH3 multiple domains protein 1, Tyrosine kinase substrate with five SH3 domains, SH3PXD2A, FISH, KIAA0418, SH3MD1, TKS5

Tested Applications

WB

Protein ID

74746151

Physical Properties

Liquid

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