EDEM3 Antibody

Product Specifications

Background

Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]) .

NCBI Gene ID

80267

Swiss Prot

Q9BZQ6

Accession Number

Q9BZQ6

Host

Rabbit

Reactivity

Human

Immunogen

This EDEM3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 774-802 amino acids from the C-terminal region of human EDEM3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

105 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

EDEM3

NCBI Official Name

ER degradation-enhancing alpha-mannosidase-like protein 3

NCBI Organism

Homo sapiens

Background Reference 01

Hirao, K., et al. J. Biol. Chem. 281 (14) :9650-9658 (2006)

Background Reference 02

Mast, S.W., et al. Glycobiology 15 (4) :421-436 (2005)

Background Reference 03

Olivari, S., et al. J. Biol. Chem. 280 (4) :2424-2428 (2005)

Background Reference 04

Sood, R., et al. Genomics 73 (2) :211-222 (2001)

Other Product Names

ER degradation-enhancing alpha-mannosidase-like protein 3, Alpha-1,2-mannosidase EDEM3, EDEM3, C1orf22

Tested Applications

Protein ID

166897965

Physical Properties

Liquid

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