AUP1 Antibody
Product Specifications
Background
This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha (IIb) subunits. These subunits play a crucial role in the integrin alpha (IIb) beta (3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25.
NCBI Gene ID
550
Swiss Prot
Q9Y679
Accession Number
Q9Y679
Host
Rabbit
Reactivity
Human
Immunogen
This AUP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 440-468 amino acids from the C-terminal region of human AUP1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Obesity
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
53 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
AUP1
NCBI Official Name
Ancient ubiquitous protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Background Reference 02
Kato, A., et al. J. Biol. Chem. 277 (32) :28934-28941 (2002)
Background Reference 03
Karpisheva, K.V., et al. Tsitologiia 44 (9) :846-851 (2002)
Background Reference 04
Karpisheva, K.V., et al. Tsitologiia 44 (9) :839-845 (2002)
Other Product Names
Ancient ubiquitous protein 1, AUP1
Tested Applications
WB
Protein ID
12643958
Physical Properties
Liquid
Curated Selection
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