MRGPRX2 Antibody

Product Specifications

Background

MRGPRX2 is the orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca (2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G (q) -coupled.

NCBI Gene ID

117194

Swiss Prot

Q96LB1

Accession Number

Q96LB1

Host

Rabbit

Reactivity

Human

Immunogen

This MRGPRX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287-315 amino acids from the C-terminal region of human MRGPRX2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction, Growth Factors

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

37 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

MRGPRX2

NCBI Official Name

Mas-related G-protein coupled receptor member X2

NCBI Organism

Homo sapiens

Background Reference 01

Gembardt, F., et al. Mol. Cell. Biochem. 319 (1-2), 115-123 (2008) :

Background Reference 02

Yang, S., et al. Gene 352, 30-35 (2005) :

Background Reference 03

Robas, N., et al. J. Biol. Chem. 278 (45) :44400-44404 (2003)

Background Reference 04

Takeda, S., et al. FEBS Lett. 520 (1-3), 97-101 (2002) :

Other Product Names

Mas-related G-protein coupled receptor member X2, MRGPRX2, MRGX2

Tested Applications

Protein ID

50401127

Physical Properties

Liquid

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