PDE1B Antibody

Product Specifications

Background

Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been classified into several families based on their biochemical properties. Members of the PDE1 family, such as PDE1B, are calmodulin (see MIM 114180) -dependent PDEs (CaM-PDEs) that are stimulated by a calcium-calmodulin complex (Repaske et al., 1992 [PubMed 1326532]) .

NCBI Gene ID

5153

Swiss Prot

Q01064

Accession Number

Q01064

Host

Rabbit

Reactivity

Human

Immunogen

This PDE1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 467-495 amino acids from the C-terminal region of human PDE1B.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

61 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PDE1B

NCBI Official Name

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

NCBI Organism

Homo sapiens

Background Reference 01

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 02

Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)

Background Reference 03

Vandeput, F., et al. J. Biol. Chem. 282 (45) :32749-32757 (2007)

Background Reference 04

Bender, A.T., et al. Proc. Natl. Acad. Sci. U.S.A. 103 (2) :460-465 (2006)

Other Product Names

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, Cam-PDE 1B, 63 kDa Cam-PDE, PDE1B, PDE1B1, PDES1B

Tested Applications

Protein ID

3183514

Physical Properties

Liquid

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