CHD1L Antibody

Product Specifications

Background

In response to DNA strand breaks, chromatin adopts a relaxed structure due to the addition of poly (ADP-ribose) (PAR) to chromatin proteins by PARP enzymes (see PARP1; MIM 173870), and this relaxation facilitates the repair of DNA damage. CHD1L interacts with PAR and has a role in chromatin relaxation following DNA damage (Ahel et al., 2009 [PubMed 19661379]) .[supplied by OMIM].

NCBI Gene ID

9557

Swiss Prot

Q86WJ1

Accession Number

Q86WJ1

Host

Rabbit

Reactivity

Human

Immunogen

This CHD1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 561-590 amino acids from the Central region of human CHD1L.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

101 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CHD1L

NCBI Official Name

Chromodomain-helicase-DNA-binding protein 1-like

NCBI Organism

Homo sapiens

Background Reference 01

Liu, C.Y., et al. Carcinogenesis 31 (7) :1259-1263 (2010)

Background Reference 02

Chen, L., et al. J. Clin. Invest. 120 (4) :1178-1191 (2010)

Background Reference 03

Ahel, D., et al. Science 325 (5945) :1240-1243 (2009)

Background Reference 04

Gottschalk, A.J., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (33) :13770-13774 (2009)

Other Product Names

Chromodomain-helicase-DNA-binding protein 1-like, Amplified in liver cancer protein 1, CHD1L, ALC1

Tested Applications

Protein ID

311033359

Physical Properties

Liquid

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