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WWTR1 Antibody

Product Specifications

Background

Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

NCBI Gene ID

25937

Swiss Prot

Q9GZV5

Accession Number

Q9GZV5

Host

Rabbit

Reactivity

Human

Immunogen

This WWTR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 370-398 amino acids from the C-terminal region of human WWTR1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=58-471

Calculated Molecular Weight

44 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

WWTR1

NCBI Official Name

WW domain-containing transcription regulator protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Remue, E., et al. FEBS Lett. 584 (19) :4175-4180 (2010)

Background Reference 02

Strakova, Z., et al. Biol. Reprod. 82 (6) :1112-1118 (2010)

Background Reference 03

Cho, H.H., et al. J. Cell. Physiol. 223 (1) :168-177 (2010)

Background Reference 04

McGeachie, M., et al. Circulation 120 (24) :2448-2454 (2009)

Other Product Names

WW domain-containing transcription regulator protein 1, Transcriptional coactivator with PDZ-binding motif, WWTR1, TAZ

Tested Applications

WB

Protein ID

67462080

Physical Properties

Liquid

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