SIAH1 Antibody

Product Specifications

Background

SIAH1 is a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq].

NCBI Gene ID

6477

Swiss Prot

Q8IUQ4

Accession Number

Q8IUQ4

Host

Rabbit

Reactivity

Human

Immunogen

This SIAH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 92-120 amino acids from the Central region of human SIAH1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

31 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SIAH1

NCBI Official Name

E3 ubiquitin-protein ligase SIAH1

NCBI Organism

Homo sapiens

Background Reference 01

Wu, H., et al. Biochem. Biophys. Res. Commun. 397 (3) :391-396 (2010)

Background Reference 02

Wen, Y.Y., et al. Mol. Carcinog. 49 (5) :440-449 (2010)

Background Reference 03

Dimitrova, Y.N., et al. J. Biol. Chem. 285 (18) :13507-13516 (2010)

Background Reference 04

Bruzzoni-Giovanelli, H., et al. J. Exp. Clin. Cancer Res. 29, 10 (2010) :

Other Product Names

E3 ubiquitin-protein ligase SIAH1, 632-, Seven in absentia homolog 1, Siah-1, Siah-1a, SIAH1, HUMSIAH

Tested Applications

Protein ID

46577493

Physical Properties

Liquid

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