YTHD2 Antibody

Product Specifications

Background

YTHDF2 is a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosme 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene.

NCBI Gene ID

51441

Swiss Prot

Q9Y5A9

Accession Number

Q9Y5A9

Host

Rabbit

Reactivity

Human

Immunogen

This YTHD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 551-579 amino acids from the C-terminal region of human YTHD2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Monkey, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

62 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

YTHDF2

NCBI Official Name

YTH domain-containing family protein 2

NCBI Organism

Homo sapiens

Background Reference 01

Nguyen, T.T., et al. Genes Chromosomes Cancer 45 (10) :918-932 (2006)

Background Reference 02

Cardelli, M., et al. J. Gerontol.Biol. Sci. Med. Sci. 61 (6) :547-556 (2006)

Background Reference 03

Rush, J., et al. Nat. Biotechnol. 23 (1) :94-101 (2005)

Background Reference 04

Stoilov, P., et al. Trends Biochem. Sci. 27 (10) :495-497 (2002)

Other Product Names

YTH domain-containing family protein 2, CLL-associated antigen KW-14, High-glucose-regulated protein 8, Renal carcinoma antigen NY-REN-2, YTHDF2, HGRG8