MDS1 Antibody

Product Specifications

Background

MDS1 is located at 3q26 170-400 kb upstream (telomeric) of EVI1 in the chromosomal region in which some of the breakpoints 5' of EVI1 have been mapped. MDS1 has been identified as a single gene as well as a previously unreported exon (s) of EVI1. MDS1 exists in normal tissues both as a unique transcript and as a normal fusion transcript with EVI1, with an additional 188 codons at the 5' end of the previously reported EVI1 open reading frame. In cells with translocation t (3;21), additional fusion transcripts are AML1-MDS1 and AML1-MDS1-EVI1. EVI1 and MDS1 are involved in leukemia associated with chromosomal translocation breakpoints in the region between these genes.

NCBI Gene ID

2122

Swiss Prot

Q13465

Accession Number

Q13465

Host

Rabbit

Reactivity

Mouse

Immunogen

This MDS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-109 amino acids from the Central region of human MDS1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

19 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

MECOM

NCBI Official Name

MDS1 and EVI1 complex locus protein MDS1

NCBI Organism

Homo sapiens

Background Reference 01

Gomez-Benito, M., et al. Br. J. Cancer 103 (8) :1292-1296 (2010)

Background Reference 02

Meyer, T.E., et al. PLoS Genet. (8) (2010) :

Background Reference 03

Goyama, S., et al. Int. J. Hematol. 91 (5) :753-757 (2010)

Background Reference 04

Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :

Other Product Names

MDS1 and EVI1 complex locus protein MDS1, Myelodysplasia syndrome 1 protein, Myelodysplasia syndrome-associated protein 1, MECOM, MDS1

Tested Applications

Physical Properties

Liquid

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