SPG20 Antibody

Product Specifications

Background

SPG20 is a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome) .

NCBI Gene ID

23111

Swiss Prot

Q8N0X7

Accession Number

Q8N0X7

Host

Rabbit

Reactivity

Human

Immunogen

This SPG20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 491-519 amino acids from the C-terminal region of human SPG20.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

73 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SPG20

NCBI Official Name

Spartin

NCBI Organism

Homo sapiens

Background Reference 01

Hooper, C., et al. BMC Biol. 8, 72 (2010) :

Background Reference 02

Milewska, M., et al. J. Neurochem. 111 (4) :1022-1030 (2009)

Background Reference 03

Tsang, H.T., et al. Hum. Mol. Genet. 18 (20) :3805-3821 (2009)

Background Reference 04

Edwards, T.L., et al. Biochem. J. 423 (1) :31-39 (2009)

Other Product Names

Spartin, Spastic paraplegia 20 protein, Trans-activated by hepatitis C virus core protein 1, SPG20, KIAA0610, TAHCCP1

Tested Applications

Protein ID

50401600

Physical Properties

Liquid

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

MBS2071144-01 0.1 mL

FITC-Linked Polyclonal Antibody to Slit Homolog 1 (Slit1)

Ask

View Details

MBS2071144-02 0.2 mL

FITC-Linked Polyclonal Antibody to Slit Homolog 1 (Slit1)

Ask

View Details

MBS2071144-03 0.5 mL

FITC-Linked Polyclonal Antibody to Slit Homolog 1 (Slit1)

Ask

View Details

MBS2071144-04 1 mL

FITC-Linked Polyclonal Antibody to Slit Homolog 1 (Slit1)

Ask

View Details

MBS2071144-05 5 mL

FITC-Linked Polyclonal Antibody to Slit Homolog 1 (Slit1)

Ask

View Details

MBS2071144-06 5x 5 mL

FITC-Linked Polyclonal Antibody to Slit Homolog 1 (Slit1)

Ask

View Details