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PNPLA6 Antibody

Product Specifications

Background

PNPLA6 is a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

NCBI Gene ID

10908

Swiss Prot

Q8IY17

Accession Number

Q8IY17

Host

Rabbit

Reactivity

Human

Immunogen

This PNPLA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1000-1029 amino acids from the C-terminal region of human PNPLA6.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=58-373

Calculated Molecular Weight

150 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PNPLA6

NCBI Official Name

Neuropathy target esterase

NCBI Organism

Homo sapiens

Background Reference 01

Hein, N.D., et al. Toxicol. Lett. 199 (1) :1-5 (2010)

Background Reference 02

Chen, J.X., et al. Pharmacol. Res. 62 (3) :259-264 (2010)

Background Reference 03

Greiner, A.J., et al. Biochim. Biophys. Acta 1798 (8) :1533-1539 (2010)

Background Reference 04

Hein, N.D., et al. Toxicol. Lett. 196 (2) :67-73 (2010)

Other Product Names

Neuropathy target esterase, Patatin-like phospholipase domain-containing protein 6, PNPLA6, NTE

Tested Applications

WB

Protein ID

150403921

Physical Properties

Liquid

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