KIDINS220 Antibody

Product Specifications

Background

KIDINS220 promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin-and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity) . Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.

NCBI Gene ID

57498

Swiss Prot

Q9ULH0

Accession Number

Q9ULH0

Host

Rabbit

Reactivity

Human

Immunogen

This KIDINS220 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1518-1547 amino acids from the C-terminal region of human KIDINS220.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

197 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

KIDINS220

NCBI Official Name

Kinase D-interacting substrate of 220 kDa

NCBI Organism

Homo sapiens

Background Reference 01

Wu, Z., et al. J. Biol. Chem. 283 (42) :28198-28215 (2008)

Background Reference 02

Sniderhan, L.F., et al. Mol. Cell. Neurosci. 38 (3) :404-416 (2008)

Background Reference 03

Li, J., et al. J. Biol. Chem. 283 (5) :2614-2621 (2008)

Background Reference 04

Liao, Y.H., et al. Cancer Res. 67 (24) :11547-11556 (2007)

Other Product Names

Kinase D-interacting substrate of 220 kDa, Ankyrin repeat-rich membrane-spanning protein, KIDINS220, ARMS, KIAA1250

Tested Applications

Protein ID

172044825

Physical Properties

Liquid

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

MBS286224-01 0.1 mg

Recombinant Human MFAP4 Protein

Ask

View Details

MBS286224-02 0.5 mg

Recombinant Human MFAP4 Protein

Ask

View Details

MBS286224-03 1 mg

Recombinant Human MFAP4 Protein

Ask

View Details

MBS286224-04 5x 1 mg

Recombinant Human MFAP4 Protein

Ask

View Details

A19740-100UG 100 µg

DNMT3A Antibody, HRP conjugated

Ask

View Details

E30P6578 20 µg

Recombinant Human ZFAND2B Protein

Ask

View Details