L1CAM Antibody

Product Specifications

Background

L1CAM is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus) . Alternative splicing of a neuron-specific exon is thought to be functionally relevant.

NCBI Gene ID

3897

Swiss Prot

P32004

Accession Number

P32004

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This L1CAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1154-1182 amino acids from the C-terminal region of human L1CAM.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

140 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

L1CAM

NCBI Official Name

Neural cell adhesion molecule L1

NCBI Organism

Homo sapiens

Background Reference 01

Schafer, M.K., et al. FEBS Lett. 584 (21) :4475-4480 (2010)

Background Reference 02

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 03

Bertolin, C., et al. J. Neurol. Sci. 294 (1-2), 124-126 (2010) :

Background Reference 04

Schafer, M.K., et al. Cell. Mol. Life Sci. 67 (14) :2425-2437 (2010)

Other Product Names

Neural cell adhesion molecule L1, N-CAM-L1, NCAM-L1, CD171, L1CAM, CAML1, MIC5

Tested Applications

Protein ID

1705571

Physical Properties

Liquid

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