CD45 Antibody

CD45 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. The CD45 gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling.

This CD45 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1245-1275 amino acids from the C-terminal region of human CD45.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Stanton, T., et al., Proc. Natl. Acad. Sci. U.S.A. 100 (10) :5997-6002 (2003) . Vogel, A., et al., Genes Immun. 4 (1) :79-81 (2003) . Rachmilewitz, J., et al., J. Biol. Chem. 278 (16) :14059-14065 (2003) . McCann, F.E., et al., J. Immunol. 170 (6) :2862-2870 (2003) . Fernandis, A.Z., et al., J. Biol. Chem. 278 (11) :9536-9543 (2003) .