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HOXB8 Antibody

Product Specifications

Background

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.

NCBI Gene ID

3218

Swiss Prot

P17481

Accession Number

P17481

Host

Rabbit

Reactivity

Human

Immunogen

This HOXB8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-243 amino acids from the C-terminal region of human HOXB8.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=58-305

Calculated Molecular Weight

28 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

HOXB8

NCBI Official Name

Homeobox protein Hox-B8

NCBI Organism

Homo sapiens

Background Reference 01

Kosaki, K., et al. Teratology 65 (2) :50-62 (2002)

Background Reference 02

Greer, J.M., et al. Neuron 33 (1) :23-34 (2002)

Background Reference 03

Knoepfler, P.S., et al. Oncogene 20 (39) :5440-5448 (2001)

Background Reference 04

Fujino, T., et al. Exp. Hematol. 29 (7) :856-863 (2001)

Other Product Names

Homeobox protein Hox-B8, Homeobox protein Hox-24, Homeobox protein Hox-2D, HOXB8, HOX2D

Tested Applications

WB

Protein ID

20141506

Physical Properties

Liquid

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