RFXANK Antibody
Product Specifications
Background
Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described for this gene, with only one isoform showing activation activity.
NCBI Gene ID
8625
Swiss Prot
O14593
Accession Number
O14593
Host
Rabbit
Reactivity
Human
Immunogen
This RFXANK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-123 amino acids from the Central region of human RFXANK.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=58-290
Calculated Molecular Weight
28 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
RFXANK
NCBI Official Name
DNA-binding protein RFXANK
NCBI Organism
Homo sapiens
Background Reference 01
Garvie, C.W., et al. Biochim. Biophys. Acta 1779 (12) :797-804 (2008)
Background Reference 02
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Background Reference 03
Krawczyk, M., et al. Mol. Cell. Biol. 25 (19) :8607-8618 (2005)
Background Reference 04
Wang, A.H., et al. J. Biol. Chem. 280 (32) :29117-29127 (2005)
Other Product Names
DNA-binding protein RFXANK, Ankyrin repeat family A protein 1, Regulatory factor X subunit B, RFX-B, Regulatory factor X-associated ankyrin-containing protein, RFXANK, ANKRA1, RFXB
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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