LOXL2 Antibody

Product Specifications

Background

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.

NCBI Gene ID

4017

Swiss Prot

Q9Y4K0

Accession Number

Q9Y4K0

Host

Rabbit

Reactivity

Human

Immunogen

This LOXL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 589-617 amino acids from the C-terminal region of human LOXL2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

87 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

LOXL2

NCBI Official Name

Lysyl oxidase homolog 2

NCBI Organism

Homo sapiens

Background Reference 01

Rodriguez, H.M., et al. J. Biol. Chem. 285 (27) :20964-20974 (2010)

Background Reference 02

Ruckert, F., et al. IntColorectal Dis 25 (3) :303-311 (2010)

Background Reference 03

Schietke, R., et al. J. Biol. Chem. 285 (9) :6658-6669 (2010)

Background Reference 04

Sano, M., et al. Int. J. Oncol. 36 (2) :321-330 (2010)

Other Product Names

Lysyl oxidase homolog 2, Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14, LOXL2

Tested Applications

Protein ID

13878585

Physical Properties

Liquid

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