MXD3 Antibody
Product Specifications
Background
This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.
NCBI Gene ID
83463
Swiss Prot
Q9BW11
Accession Number
Q9BW11
Host
Rabbit
Reactivity
Human
Immunogen
This MXD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-56 amino acids from the N-terminal region of human MXD3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
23 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
MXD3
NCBI Official Name
Max dimerization protein 3
NCBI Organism
Homo sapiens
Background Reference 01
Barisone, G.A., et al. Cell Cycle 7 (4) :423-427 (2008)
Background Reference 02
Yun, J.S., et al. Mol. Cell. Biol. 27 (23) :8178-8189 (2007)
Background Reference 03
Hurlin, P.J., et al. Semin. Cancer Biol. 16 (4) :265-274 (2006)
Background Reference 04
Sommer, A., et al. J. Biol. Chem. 273 (12) :6632-6642 (1998)
Other Product Names
Max dimerization protein 3, Max dimerizer 3, Class C basic helix-loop-helix protein 13, bHLHc13, Max-associated protein 3, Max-interacting transcriptional repressor MAD3, Myx, MXD3, BHLHC13, MAD3
Tested Applications
WB
Protein ID
74733390
Physical Properties
Liquid
Frequently Asked Questions
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