MXD3 Antibody

Product Specifications

Background

This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.

NCBI Gene ID

83463

Swiss Prot

Q9BW11

Accession Number

Q9BW11

Host

Rabbit

Reactivity

Human

Immunogen

This MXD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-56 amino acids from the N-terminal region of human MXD3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

23 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

MXD3

NCBI Official Name

Max dimerization protein 3

NCBI Organism

Homo sapiens

Background Reference 01

Barisone, G.A., et al. Cell Cycle 7 (4) :423-427 (2008)

Background Reference 02

Yun, J.S., et al. Mol. Cell. Biol. 27 (23) :8178-8189 (2007)

Background Reference 03

Hurlin, P.J., et al. Semin. Cancer Biol. 16 (4) :265-274 (2006)

Background Reference 04

Sommer, A., et al. J. Biol. Chem. 273 (12) :6632-6642 (1998)

Other Product Names

Max dimerization protein 3, Max dimerizer 3, Class C basic helix-loop-helix protein 13, bHLHc13, Max-associated protein 3, Max-interacting transcriptional repressor MAD3, Myx, MXD3, BHLHC13, MAD3