ACTR1A Antibody

Product Specifications

Background

This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin.

NCBI Gene ID

10121

Swiss Prot

P61163

Accession Number

P61163

Host

Rabbit

Reactivity

Mouse

Immunogen

This ACTR1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-126 amino acids from the Central region of human ACTR1A.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Monkey, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

43 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

ACTR1A

NCBI Official Name

Alpha-centractin

NCBI Organism

Homo sapiens

Background Reference 01

Sugarbaker, D.J., et al. Proc. Natl. Acad. Sci. U.S.A. 105 (9) :3521-3526 (2008)

Background Reference 02

Petretti, C., et al. EMBO Rep. 7 (4) :418-424 (2006)

Background Reference 03

Casenghi, M., et al. Dev. Cell 5 (1) :113-125 (2003)

Background Reference 04

Carew, J.A., et al. J. Thromb. Haemost. 1 (6) :1220-1227 (2003)

Other Product Names

Alpha-centractin, Centractin, ARP1, Actin-RPV, Centrosome-associated actin homolog, ACTR1A, CTRN1

Tested Applications

Protein ID

47117651

Physical Properties

Liquid

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