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Mouse Hck Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may play a role in the innate immune response and the STAT5 signaling pathway. Alternative translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization.

NCBI Gene ID

15162

Swiss Prot

P08103

Accession Number

P08103

Host

Rabbit

Reactivity

Human

Immunogen

This Mouse Hck antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-101 amino acids from the N-terminal region of mouse Hck.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

59 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

Hck

NCBI Official Name

Tyrosine-protein kinase HCK

NCBI Organism

Mus musculus

Background Reference 01

Verollet, C., et al. J. Immunol. 184 (12) :7030-7039 (2010)

Background Reference 02

Ruschmann, J., et al. Exp. Hematol. 38 (5) :392-402 (2010)

Background Reference 03

Lowell, C.A., et al. J. Cell Biol. 133 (4) :895-910 (1996)

Background Reference 04

Lowell, C.A., et al. Blood 87 (5) :1780-1792 (1996)

Other Product Names

Tyrosine-protein kinase HCK, B-cell/myeloid kinase, BMK, Hematopoietic cell kinase, Hemopoietic cell kinase, p56-HCK/p59-HCK, Hck

Tested Applications

WB

Physical Properties

Liquid

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