LIG3 Antibody
Product Specifications
Background
This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized.
NCBI Gene ID
3980
Swiss Prot
P49916
Accession Number
P49916
Host
Rabbit
Reactivity
Human
Immunogen
This LIG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 793-822 amino acids from the C-terminal region of human LIG3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
113 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
LIG3
NCBI Official Name
DNA ligase 3
NCBI Organism
Homo sapiens
Background Reference 01
Wang, W., et al. Nucleic Acids Res. (2010) In press :
Background Reference 02
Arora, M., et al. Leukemia 24 (8) :1470-1475 (2010)
Background Reference 03
Cotner-Gohara, E., et al. Biochemistry 49 (29) :6165-6176 (2010)
Background Reference 04
Ho-Pun-Cheung, A., et al. Pharmacogenomics J. (2010) In press :
Other Product Names
DNA ligase 3, DNA ligase III, Polydeoxyribonucleotide synthase [ATP] 3, LIG3
Tested Applications
WB
Protein ID
251757259
Physical Properties
Liquid
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