TRAF4 Antibody

Product Specifications

Background

This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD (P) H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.

NCBI Gene ID

9618

Swiss Prot

Q9BUZ4

Accession Number

Q9BUZ4

Host

Rabbit

Reactivity

Human

Immunogen

This TRAF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 427-455 amino acids from the C-terminal region of human TRAF4.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

54 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

TRAF4

NCBI Official Name

TNF receptor-associated factor 4

NCBI Organism

Homo sapiens

Background Reference 01

Li, S., et al. Mol. Cell. Biochem. 338 (1-2), 11-17 (2010) :

Background Reference 02

Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)

Background Reference 03

Segat, L., et al. Vaccine 28 (10) :2201-2206 (2010)

Background Reference 04

Albers, H.M., et al. Ann. Rheum. Dis. 67 (11) :1578-1580 (2008)

Other Product Names

TNF receptor-associated factor 4, Cysteine-rich domain associated with RING and Traf domains protein 1, Metastatic lymph node gene 62 protein, MLN 62, RING finger protein 83, TRAF4, CART1, MLN62, RNF83