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SORD Antibody

Product Specifications

Background

Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]) . The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD (+) cofactor.

NCBI Gene ID

6652

Swiss Prot

Q00796

Accession Number

Q00796

Host

Rabbit

Reactivity

Human

Immunogen

This SORD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 211-239 amino acids from the Central region of human SORD.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=58-227

Calculated Molecular Weight

38 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SORD

NCBI Official Name

Sorbitol dehydrogenase

NCBI Organism

Homo sapiens

Background Reference 01

Szabo, Z., et al. Oncol. Rep. 23 (5) :1233-1239 (2010)

Background Reference 02

Johnatty, S.E., et al. PLoS Genet. (7), E1001016 (2010) :

Background Reference 03

El-Kabbani, O., et al. Curr. Med. Chem. 11 (4) :465-476 (2004)

Background Reference 04

Pauly, T.A., et al. Structure 11 (9) :1071-1085 (2003)

Other Product Names

Sorbitol dehydrogenase, L-iditol 2-dehydrogenase, SORD

Tested Applications

WB

Protein ID

292495088

Physical Properties

Liquid

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