SORD Antibody
Product Specifications
Background
Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]) . The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD (+) cofactor.
NCBI Gene ID
6652
Swiss Prot
Q00796
Accession Number
Q00796
Host
Rabbit
Reactivity
Human
Immunogen
This SORD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 211-239 amino acids from the Central region of human SORD.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
38 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SORD
NCBI Official Name
Sorbitol dehydrogenase
NCBI Organism
Homo sapiens
Background Reference 01
Szabo, Z., et al. Oncol. Rep. 23 (5) :1233-1239 (2010)
Background Reference 02
Johnatty, S.E., et al. PLoS Genet. (7), E1001016 (2010) :
Background Reference 03
El-Kabbani, O., et al. Curr. Med. Chem. 11 (4) :465-476 (2004)
Background Reference 04
Pauly, T.A., et al. Structure 11 (9) :1071-1085 (2003)
Other Product Names
Sorbitol dehydrogenase, L-iditol 2-dehydrogenase, SORD
Tested Applications
WB
Protein ID
292495088
Physical Properties
Liquid
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