NEIL2 Antibody

Product Specifications

Background

NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226])

NCBI Gene ID

252969

Swiss Prot

Q969S2

Accession Number

Q969S2

Host

Rabbit

Reactivity

Human

Immunogen

This NEIL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-96 amino acids from the N-terminal region of human NEIL2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

37 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

NEIL2

NCBI Official Name

Endonuclease 8-like 2

NCBI Organism

Homo sapiens

Background Reference 01

Briggs, F.B., et al. Am. J. Epidemiol. 172 (2) :217-224 (2010)

Background Reference 02

Monsees, G.M., et al. Breast Cancer Res. Treat. (2010) In press :

Background Reference 03

Grin, I.R., et al. Biochem. Biophys. Res. Commun. 394 (1) :100-105 (2010)

Background Reference 04

Kinslow, C.J., et al. Genes Chromosomes Cancer 47 (11) :923-932 (2008)

Other Product Names

Endonuclease 8-like 2, 322-, DNA glycosylase/AP lyase Neil2, DNA- (apurinic or apyrimidinic site) lyase Neil2, Endonuclease VIII-like 2, Nei homolog 2, NEH2, Nei-like protein 2, NEIL2