Connexin 50 Antibody

GJA8 is a an integral membrane protein that belongs to the connexin family, alpha-type (group II) subfamily. One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. This particular connexin only forms junctional channels. GJA8 is expressed in the eye lens, and defects in GJA8 are the cause of zonular pulverulent cataract type 1 (CZP1), a form of autosomal dominant congenital cataract.

This Connexin 50 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 402-433 amino acids from the C-terminal region of human Connexin 50.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Shiels, A., et al., Am. J. Hum. Genet. 62 (3) :526-532 (1998) . Church, R.L., et al., Curr. Eye Res. 14 (10) :979-981 (1995) . Church, R.L., et al., Curr. Eye Res. 14 (3) :215-221 (1995) .