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Connexin 37 Antibody

Product Specifications

Background

Gap junctions permit direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular communication. Gap junction channels consist of connexin protein subunits encoded by a multigene family. Erythrokeratodermia variabilis (EKV) is an autosomal dominant disorder of keratinization characterized by migratory erythematous lesions and fixed keratotic plaques. Mutations in the GJB3 gene have been reported in some but not all families, although it has been postulated that the absence of connexin 30.3 can be compensated by other connexins.

NCBI Gene ID

2701

Swiss Prot

P35212

Accession Number

P35212

Host

Rabbit

Reactivity

Mouse

Immunogen

This Connexin 37 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 303-333 amino acids from the C-terminal region of human Connexin 37.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=58-178

Calculated Molecular Weight

37 kDa

Fragment

Rabbit Ig

Symbol

GJA4

NCBI Official Name

Gap junction alpha-4 protein

NCBI Organism

Homo sapiens

Background Reference 01

Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99 (26) :16899-16903 (2002) .

Background Reference 02

Saito, T., et al., Int. J. Cancer 86 (1) :67-70 (2000) .

Background Reference 03

Boerma, M., et al., J. Intern. Med. 246 (2) :211-218 (1999) .

Background Reference 04

Krutovskikh, V., et al., Carcinogenesis 17 (8) :1761-1763 (1996) .

Other Product Names

Gap junction alpha-4 protein, Connexin-37, Cx37, GJA4

Tested Applications

WB, IHC-P

Protein ID

8928555

Physical Properties

Liquid

Curated Selection

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