Connexin 37 Antibody
Product Specifications
Background
Gap junctions permit direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular communication. Gap junction channels consist of connexin protein subunits encoded by a multigene family. Erythrokeratodermia variabilis (EKV) is an autosomal dominant disorder of keratinization characterized by migratory erythematous lesions and fixed keratotic plaques. Mutations in the GJB3 gene have been reported in some but not all families, although it has been postulated that the absence of connexin 30.3 can be compensated by other connexins.
NCBI Gene ID
2701
Swiss Prot
P35212
Accession Number
P35212
Host
Rabbit
Reactivity
Mouse
Immunogen
This Connexin 37 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 303-333 amino acids from the C-terminal region of human Connexin 37.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein G column, followed by dialysis against PBS.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
37 kDa
Fragment
Rabbit Ig
Symbol
GJA4
NCBI Official Name
Gap junction alpha-4 protein
NCBI Organism
Homo sapiens
Background Reference 01
Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99 (26) :16899-16903 (2002) .
Background Reference 02
Saito, T., et al., Int. J. Cancer 86 (1) :67-70 (2000) .
Background Reference 03
Boerma, M., et al., J. Intern. Med. 246 (2) :211-218 (1999) .
Background Reference 04
Krutovskikh, V., et al., Carcinogenesis 17 (8) :1761-1763 (1996) .
Other Product Names
Gap junction alpha-4 protein, Connexin-37, Cx37, GJA4
Tested Applications
WB, IHC-P
Protein ID
8928555
Physical Properties
Liquid
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