Connexin 30.3 Antibody

Product Specifications

Background

Gap junctions permit direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular communication. Gap junction channels consist of connexin protein subunits encoded by a multigene family. Erythrokeratodermia variabilis (EKV) is an autosomal dominant disorder of keratinization characterized by migratory erythematous lesions and fixed keratotic plaques. Mutations in the GJB3 gene have been reported in some but not all families, although it has been postulated that the absence of connexin 30.3 can be compensated by other connexins.

NCBI Gene ID

127534

Swiss Prot

Q9NTQ9

Accession Number

Q9NTQ9

Host

Rabbit

Reactivity

Human

Immunogen

This Connexin 30.3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-120 amino acids from the N-terminal region of human Connexin 30.3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

30 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

GJB4

NCBI Official Name

Gap junction beta-4 protein

NCBI Organism

Homo sapiens

Background Reference 01

Ota, T., et al., Nat. Genet. 36 (1) :40-45 (2004) .

Background Reference 02

Richard, G., et al., J. Invest. Dermatol. 120 (4) :601-609 (2003) .

Background Reference 03

Macari, F., et al., Am. J. Hum. Genet. 67 (5) :1296-1301 (2000) .

Background Reference 04

Lopez-Bigas, N., et al., Hum. Mutat. 19 (4), 458 (2002) .

Other Product Names

Gap junction beta-4 protein, Connexin-303, Cx303, GJB4

Tested Applications

Protein ID

12229761

Physical Properties

Liquid

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

MBS2018276-01 0.01 mg

Recombinant Fibroblast Growth Factor Receptor 2 (FGFR2)

Ask

View Details

MBS2018276-02 0.05 mg

Recombinant Fibroblast Growth Factor Receptor 2 (FGFR2)

Ask

View Details

MBS2018276-03 0.1 mg

Recombinant Fibroblast Growth Factor Receptor 2 (FGFR2)

Ask

View Details

MBS2018276-04 0.2 mg

Recombinant Fibroblast Growth Factor Receptor 2 (FGFR2)

Ask

View Details

MBS2018276-05 0.5 mg

Recombinant Fibroblast Growth Factor Receptor 2 (FGFR2)

Ask

View Details

MBS2018276-06 1 mg

Recombinant Fibroblast Growth Factor Receptor 2 (FGFR2)

Ask

View Details