TLR7 Antibody
Product Specifications
Background
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR7 is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X.
NCBI Gene ID
51284
Swiss Prot
Q9NYK1
Accession Number
Q9NYK1
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This TLR7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-128 amino acids from the N-terminal region of human TLR7.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=58-165
Calculated Molecular Weight
121 kDa
Fragment
Rabbit Ig
Symbol
TLR7
NCBI Official Name
Toll-like receptor 7
NCBI Organism
Homo sapiens
Background Reference 01
Clark, H.F., et al., Genome Res. 13 (10) :2265-2270 (2003) .
Background Reference 02
Ito, T., et al., J. Exp. Med. 195 (11) :1507-1512 (2002) .
Background Reference 03
Du, X., et al., Eur. Cytokine Netw. 11 (3) :362-371 (2000) .
Background Reference 04
Chuang, T.H., et al., Eur. Cytokine Netw. 11 (3) :372-378 (2000) .
Other Product Names
Toll-like receptor 7, TLR7
Tested Applications
WB, IHC-P
Protein ID
20140876
Physical Properties
Liquid
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