SAP18 Antibody
Product Specifications
Background
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2.
NCBI Gene ID
10284
Swiss Prot
O00422
Accession Number
O00422
Host
Rabbit
Reactivity
Human
Immunogen
This SAP18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the Central region of human SAP18.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
18 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SAP18
NCBI Official Name
Histone deacetylase complex subunit SAP18
NCBI Organism
Homo sapiens
Background Reference 01
Sorin, M., et al. PLoS Pathog. (6), E1000463 (2009) :
Background Reference 02
McCallum, S.A., et al. Biochemistry 45 (39) :11974-11982 (2006)
Background Reference 03
Joselin, A.P., et al. J. Biol. Chem. 281 (18) :12475-12484 (2006)
Background Reference 04
Schwerk, C., et al. Mol. Cell. Biol. 23 (8) :2981-2990 (2003)
Other Product Names
Histone deacetylase complex subunit SAP18, 18 kDa Sin3-associated polypeptide, 2HOR0202, Cell growth-inhibiting gene 38 protein, Sin3-associated polypeptide p18, SAP18
Tested Applications
WB
Physical Properties
Liquid
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