SAP18 Antibody

Product Specifications

Background

Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2.

NCBI Gene ID

10284

Swiss Prot

O00422

Accession Number

O00422

Host

Rabbit

Reactivity

Human

Immunogen

This SAP18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the Central region of human SAP18.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

18 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SAP18

NCBI Official Name

Histone deacetylase complex subunit SAP18

NCBI Organism

Homo sapiens

Background Reference 01

Sorin, M., et al. PLoS Pathog. (6), E1000463 (2009) :

Background Reference 02

McCallum, S.A., et al. Biochemistry 45 (39) :11974-11982 (2006)

Background Reference 03

Joselin, A.P., et al. J. Biol. Chem. 281 (18) :12475-12484 (2006)

Background Reference 04

Schwerk, C., et al. Mol. Cell. Biol. 23 (8) :2981-2990 (2003)

Other Product Names

Histone deacetylase complex subunit SAP18, 18 kDa Sin3-associated polypeptide, 2HOR0202, Cell growth-inhibiting gene 38 protein, Sin3-associated polypeptide p18, SAP18