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MXI1 Antibody

Product Specifications

Background

Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.

NCBI Gene ID

4601

Swiss Prot

P50539

Accession Number

P50539

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This MXI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-82 amino acids from the Central region of human MXI1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=58-142

Calculated Molecular Weight

26 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

MXI1

NCBI Official Name

Max-interacting protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Lofstedt, T., et al. Exp. Cell Res. 315 (11) :1924-1936 (2009)

Background Reference 02

Baranzini, S.E., et al. Hum. Mol. Genet. 18 (4) :767-778 (2009)

Background Reference 03

Tsao, C.C., et al. Cancer Biol. Ther. 7 (10) :1619-1627 (2008)

Background Reference 04

Suo, X.H., et al. Zhonghua Xue Ye Xue Za Zhi 28 (11) :745-749 (2007)

Other Product Names

Max-interacting protein 1, Max interactor 1, Class C basic helix-loop-helix protein 11, bHLHc11, MXI1, BHLHC11

Tested Applications

WB

Protein ID

116242666

Physical Properties

Liquid

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