AZU1 Antibody
Product Specifications
Background
Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. The protein encoded by this gene is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.
NCBI Gene ID
566
Swiss Prot
P20160
Accession Number
P20160
Host
Rabbit
Reactivity
Human
Immunogen
This AZU1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-96 amino acids from the Central region of human AZU1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
27 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
AZU1
NCBI Official Name
Azurocidin
NCBI Organism
Homo sapiens
Background Reference 01
Changho, S., et al. Pathol. Res. Pract. 206 (5) :314-317 (2010)
Background Reference 02
Linder, A., et al. J. Invest. Dermatol. 130 (5) :1365-1372 (2010)
Background Reference 03
Segat, L., et al. Vaccine 28 (10) :2201-2206 (2010)
Background Reference 04
Wilker, E., et al. Environ. Health Perspect. 117 (6) :935-940 (2009)
Other Product Names
Azurocidin, Cationic antimicrobial protein CAP37, Heparin-binding protein, HBP, AZU1
Tested Applications
WB
Protein ID
416746
Physical Properties
Liquid
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